Losing the will to live
Losing the will to live was a serious medical condition suffered by losers, wimps and wienies when confronted with life circumstances beyond their ability to cope. Most notably suffered by Padmé Amidala after losing the love of evil emo Sith Lord Anakin Skywalker... even though she insisted "There is good in him" and she had just given birth to twins, who presumably would grow up more stable and well adjusted with their biological mother, she just couldn't summon the will to care and died.
One way to overcome losing the will to live was to shout NOOOOOOOOOOO!!! and then get on with life.
Other well-documented examples of losing the will to live include the... eh... ah, what's the point? I just can't go on... aaaarrrrrrgggghhhhhh... eeeggghhh...